We Know IBD - Duet UC

The DUET-UC Study is evaluating the safety and efficacy of a combination of two investigational medications compared with placebo in adults with moderately to severely active ulcerative colitis (UC).

See If You Are Eligible


There have been a growing number of approved treatments for UC over the years, thanks to clinical research and those who have participated. But there is still a need to find treatments that work for those impacted the most. The DUET-UC Study is one of the few clinical trials, so far, that is evaluating combinations of investigational biologics that may one day be an option for those with UC.

You may be able to take part in the DUET-UC Study if you:

  • Are 18 to 65 years old
  • Have had a diagnosis of ulcerative colitis for at least 3 months
  • Are currently experiencing a reappearance or worsening of your ulcerative colitis symptoms, called a flare, which may include:
    • Frequent and/or urgent bowel movements
    • Abdominal pain
    • Lack of appetite
    • Diarrhea
    • Rectal bleeding
  • Have been unsuccessful with previous medications to treat your ulcerative colitis

Additional eligibility criteria will be assessed by the trial doctor or staff.